MDM2 309 T/ G Polymorphism Is Associated With Acute Myeloid Leukemia: A Meta-Analysis

Objective:The 309 T/G polymorphism of murine double minute 2 (MDM2) gene is associated with acute myeloid leukemia, but conflicting results have been reported. In this study, we performed a meta-analysis to estimate the association between MDM2 309 T/G polymorphism and acute myeloid leukemia risk. Methods: Electronic search of PubMed was conducted to select case-control studies that contain available genotype frequencies of the MDM2 309 T/G polymorphism. Pooled Odds Ratio (OR) with 95% Confidence Interval (CI) was used to assess the strength of the association. Results: Six case-control studies, which consist of 1121 cases and 3974 controls, were identified. After pooling all the eligible studies in the meta-analysis, we found that the MDM2 309 T/G polymorphism was significantly associated with risk of acute myeloid leukemia (Recessive model G/G versus T-carriers: OR=1.738, 95% CI: 1.424 – 2.122, p= 0.000; additive model G versus T: OR = 1.298, 95% CI: 1.159– 1.453, p= 0.000). Symmetrical funnel plot derived from Egger’s test (P=0.970) and Begg’s test (P=0.851) indicated the lack of publication bias. Discussion: This meta-analysis suggests that individuals with T/G or G/G genotype of MDM2 SNP309 were significantly associated with increased acute myeloid leukemia risk. To draw comprehensive and true conclusions, well-designed studies with large sample sizes and representing different ethnicities are required.